Vinculación del virólogo profesor Adolfo García Sastre con la Universidad de Salamanca y con la Real Academia Nacional de Farmacia / Relationship of the virologist professor Adolfo García Sastre with the University of Salamanca and the Royal National Academy of Pharmacy

Se detallan y comentan algunos datos biográficos relativos al virólogo Profesor Adolfo García Sastre correspondientes a su etapa como estudiante en la Facultad de Biología de la Universidad de Salamanca, durante los cursos finales de su Licenciatura (años 1981-1986), así como a los siguientes en que realizó su Tesis de Licenciatura (Tesina) en 1986,y Doctorado (1986-1990), en el Departamento de Bioquímica y Biología Molecular de dicha Facultad (Director: Prof.J.A. Cabezas); habiendo obtenido en ambas las máximas calificaciones y el Premio Extraordinario en la de Doctorado. También se resumen las líneas de investigación que cultivó en Salamanca hasta 1991 en colaboración con el director de ambas Tesis (el Profesor Titular Enrique Villar), el Profesor J.A. Cabezas y, a veces, otros. Los resultados obtenidos, así como los derivados de su breve etapa inmediata en el Instituto Pasteur de Paris, en coordinación con el Departamentos almantino, fueron publicados en revistas de Virología o de Bioquímica de gran prestigio y presentados en congresos nacionales e internacionales. Posteriormente, en su etapa americana en el Mount Sinai de Nueva York, entró en contacto con el Profesor Mariano Esteban, entonces trabajando en el Down state Medical Center de New York, SUNY, y ambos, conjuntamente con el grupo del New York University (NYU) dirigido por Ruth Nussenweig y Fidel Zavala, llevaron a cabo experimentos seminales de inmunología que abrieron las bases a la combinación de vacunas en protocolos prime/boosty activación de linfocitos TCD8+ con resultado de alta eficacia frente a patógenos. Estos protocolos están siendo implementados en numerosos ensayos preclínicos y clínicos. La contribución del Prof. García Sastre a la ciencia está actualmente en fase exponencial, abriendo nuevos horizontes en el entendimiento de la biología molecular de virus emergentes, su patología, interacción virus-hospedador y desarrollando nuevos procedimientos de control viral

Se detallan y comentan algunos datos biográficos relativos al virólogo Profesor Adolfo García Sastre correspondientes in the Biology School of University of Salamanca and during his PhD Thesis (1986-1990) in the Department of Biochemistry and Molecular Biology (Chairman Prof J.A. Cabezas), under the supervision of Prof. Enrique Villlar and obtaining the highest academic marks. The research lines that he established in collaboration with his Thesis director, with Prof.J.A Cabezas and others, as well as his results during his stay at the Pasteur Institute in Paris, are also highlighted. His findings in this period were published in prestigious Virology and Biochemistry journals and presented at national and international meetings. Thereafter, when he moved to Mount Sinai in New York, he met Prof Mariano Esteban, then working at Downstate Medical Center in New York, SUNY, and both, in collaboration with the group of Prof. Ruth Nus-senzweig and Fidel Zavala at New York University, set up seminal immunological studies that are the basis for combined vaccination approaches, prime/boost and activation of CD8+ T cells, now widely used in preclinical and clinical studies. The scientific research contributions of Prof. García Sastre are growing at an exponential rate, opening new horizon sin understanding the molecular biology of emerging viruses, their pathology virus-host cell interactions and strategies of virus control

[Regulation of drug prices in nineteenth-century Bazilian pharmacy]. / O Regimento dos preços dos medicamentos... na farmácia brasileira oitocentista.

On November 5th, 1808, D. João de Bragança issued a license about the practice of druggists and the price of drugs and ordered the creation of a regulation to tax the cost of medicines marketed in Brazil. First published on 1809, the Regimento dos preços dos medicamentos... gained new editions in the following years and became an indispensable working tool for those involved in the making and trading of drugs at this time. This paper situates historically and sheds light on a document briefly explored by the researchers of the history of the Brazilian pharmacy, taking into account that it was one of the first initiatives of the Luso-Brazilian government in line with the pharmaceutical activity in Brazil in the nineteenth century.

Em 5 de novembro de 1808, dom João de Bragança promulgou um alvará sobre o exercício dos boticários e o preço das drogas e ordenou a criação de um regulamento para taxar o custo dos medicamentos comercializados no Brasil. Publicado pela primeira vez em 1809, o Regimento dos preços dos medicamentos... ganhou novas edições nos anos subsequentes e tornou-se um indispensável instrumento de trabalho para os envolvidos com a feitura e o comércio dos remédios. Este texto situa historicamente e destaca esse documento brevemente explorado pelos pesquisadores da história da farmácia brasileira, visto ter sido uma das primeiras iniciativas do governo luso-brasileiro condizentes com a atividade farmacêutica no Brasil no século XIX.

O Regimento dos preços dos medicamentos... na farmácia brasileira oitocentista / Regulation of drug prices in nineteenth-century Bazilian pharmacy

Resumo Em 5 de novembro de 1808, dom João de Bragança promulgou um alvará sobre o exercício dos boticários e o preço das drogas e ordenou a criação de um regulamento para taxar o custo dos medicamentos comercializados no Brasil. Publicado pela primeira vez em 1809, o Regimento dos preços dos medicamentos... ganhou novas edições nos anos subsequentes e tornou-se um indispensável instrumento de trabalho para os envolvidos com a feitura e o comércio dos remédios. Este texto situa historicamente e destaca esse documento brevemente explorado pelos pesquisadores da história da farmácia brasileira, visto ter sido uma das primeiras iniciativas do governo luso-brasileiro condizentes com a atividade farmacêutica no Brasil no século XIX.

Abstract On November 5th, 1808, D. João de Bragança issued a license about the practice of druggists and the price of drugs and ordered the creation of a regulation to tax the cost of medicines marketed in Brazil. First published on 1809, the Regimento dos preços dos medicamentos... gained new editions in the following years and became an indispensable working tool for those involved in the making and trading of drugs at this time. This paper situates historically and sheds light on a document briefly explored by the researchers of the history of the Brazilian pharmacy, taking into account that it was one of the first initiatives of the Luso-Brazilian government in line with the pharmaceutical activity in Brazil in the nineteenth century.

Looking Back at US Pharmacy's Past to Help Discern Its Future.

Objective: To review specific literature that aimed to predict the future of US pharmacy, beginning in the late 1980s. Data Sources: Articles were identified from searching MEDLINE, CINAHL, Google Scholar, and references of relevant articles. The following combinations of search terms were used: future, pharmacy, prediction, and forecast. Study Selection and Data Extraction: The following inclusion criteria were applied: (1) full-text commentary, review, or original research and (2) focused predominantly on the pharmacy in the United States. Data on predictions for the future of pharmacy were extracted. Data Synthesis: We selected 3 articles published between 1988 and 2006, with each aiming to project the future for the following decade. We examined each prediction in light of the current knowledge. Relevance to Patient Care and Clinical Practice: Educators, practitioners, and other stakeholders should consider reflecting on the changes in pharmacy for the past 3 decades and applying both historical and emerging trends to improve patient care and sustain practice in the third decade of the 21st century and beyond. Conclusion: Most of the predictions for the future of pharmacy from the past 3 decades materialized, with some still in progress (reimbursement for pharmacy services), whereas others manifested in unexpected ways (transition from shortage to excess of pharmacists). Current forces shaping pharmacy include, but are not limited to, growing spending and use of specialty drugs, automation of pharmacy operations, growth of pharmacy in the digital health enterprise, and growing consumer interest in the use of analytical pharmacy that tests drugs before dispensing.

Cuando todo era urgente / When everything was urgent

No disponible

[The "homeopathic specific:" commercial legitimization of homeopathy in Barcelona (1902-1910)]. / El "específico homeopático": legitimación comercial de la homeopatía en Barcelona (1902-1910).

The change in position of homeopathic remedies in the health market produced by the emerging pharmacological paradigm was key to the popularization of homeopathy in Spain. The introduction of specifics and their marketing strategies led to a rise in popular legitimization of homeopathy, and the battles between different professionals created fertile ground for explaining and promoting this doctrine. This article analyzes a contextualized case in Barcelona in the early twentieth century, and explores from different perspectives the new role of pharmacists and medications in spreading homeopathy, centering on strategies for popularizing homeopathic remedies in Spain.

El cambio en la posición que ocupaban los remedios homeopáticos en el mercado de la salud, derivado del emergente paradigma farmacológico, fue clave en la popularización de la homeopatía en España. La introducción de los específicos y sus técnicas de publicidad originó un aumento en la legitimación popular de la homeopatía y encontró en las pugnas entre diferentes profesionales un terreno abonado para la divulgación y la promoción de esta doctrina. El artículo analiza un caso de estudio contextualizado en Barcelona a principios del siglo XX, aproximándose desde diferentes perspectivas al nuevo rol del farmacéutico y el medicamento como divulgadores de la homeopatía y centrándose en las estrategias de la popularización de los remedios homeopáticos en España.

[Insights into Hangzhou patent medicine industry business characteristics in Qing dynasty from drug indexes of three large pharmacies].

Drug Indexes are of significance for investigation on ancient patent medicine industry. Herein, we compared Zhang Tongtai Wan San Gao Dan Quanlu (10th year of Jiaqing Reign, 1805), Ye Zhongde Tang Dan Wan Quanlu (4th year of Xianfeng Reign, 1854 and 5th year of Tongzhi Reign, 1866) and Hu Qingyu Tang Wan San Gao Dan Quanji(3th year of Guangxu Reign, 1877) to illustrate the business features of Hangzhou patent medicine industry in Qing Dynasty.The three pharmacies, Zhang Tongtai Tang, Ye Zhongde Tang and Hu Qingyu Tang, were all adept in utilizing ancient prescriptions that contained various preparations, emphasized commercial ethics and product qualities, distributed their products in flexible pattern and focused on distillation formula. Moreover, each of the three pharmacies exhibited their own characteristics in product types and commercialization.

El " específico homeopático ": legitimación comercial de la homeopatía en Barcelona (1902-1910) / The " homeopathic specific: " commercial legitimization of homeopathy in Barcelona (1902-1910)

Resumen El cambio en la posición que ocupaban los remedios homeopáticos en el mercado de la salud, derivado del emergente paradigma farmacológico, fue clave en la popularización de la homeopatía en España. La introducción de los específicos y sus técnicas de publicidad originó un aumento en la legitimación popular de la homeopatía y encontró en las pugnas entre diferentes profesionales un terreno abonado para la divulgación y la promoción de esta doctrina. El artículo analiza un caso de estudio contextualizado en Barcelona a principios del siglo XX, aproximándose desde diferentes perspectivas al nuevo rol del farmacéutico y el medicamento como divulgadores de la homeopatía y centrándose en las estrategias de la popularización de los remedios homeopáticos en España.

Abstract The change in position of homeopathic remedies in the health market produced by the emerging pharmacological paradigm was key to the popularization of homeopathy in Spain. The introduction of specifics and their marketing strategies led to a rise in popular legitimization of homeopathy, and the battles between different professionals created fertile ground for explaining and promoting this doctrine. This article analyzes a contextualized case in Barcelona in the early twentieth century, and explores from different perspectives the new role of pharmacists and medications in spreading homeopathy, centering on strategies for popularizing homeopathic remedies in Spain.

Distribución geográfica de la industria farmacéutica madrileña durante el Franquismo / Geographical distribution of the pharmaceutical industry from Madrid during Francoism

Este estudio analiza la influencia de los planes urbanísticos, de ordenación del territorio y de descongestión industrial, trazados tanto por el Ayuntamiento de Madrid como por el Gobierno de la Nación, sobre la localización de la industria farmacéutica instalada en la ciudad de Madrid y su entorno provincial, lo que nos lleva a valorar las coincidencias y las singularidades de este tipo de industria respecto del resto de establecimientos que vertebraron el espacio industrial madrileño durante el Franquismo

This paper analyzes the influence of the urban planning, territorial planning and industrial decongestion plans, drawn up both by the Madrid’s City Council and by the Government of the Nation, on the location of the pharmaceutical industry installed in the city of Madrid and its provincial environment, which leads us to assess the coincidences and singularities of this type of industry with respect to the rest of the establishments that formed the backbone of Madrid's industrial space during the Franco regime

The Psychopharmacological Revolution in the USSR: Schizophrenia Treatment and the Thaw in Soviet Psychiatry, 1954-64.

Twentieth-century psychiatry was transformed in the 1950s and 1960s by the introduction of powerful psychopharmaceuticals, particularly Chlorpromazine (Thorazine). This paper examines the reception of Chlorpromazine in the Soviet Union and its effect on the Soviet practice of psychiatry. The drug, known in the USSR by the name Aminazine, was first used in Moscow in 1954 and was officially approved in 1955. I argue that Soviet psychiatrists initially embraced it because Aminazine enabled them to successfully challenge the Stalin-era dogma in their field (Ivan Pavlov's 'theory of higher nervous activity'). Unlike in the West, however, the new psychopharmaceuticals did not lead to deinstitutionalisation. I argue that the new drugs did not disrupt the existing Soviet system because, unlike the system in the West, the Soviets were already dedicated, at least in theory, to a model which paired psychiatric hospitals with community-based 'neuropsychiatric dispensaries.' Chlorpromazine gave this system a new lease on life, encouraging Soviet psychiatrists to more rapidly move patients from in-patient treatment to 'supporting' treatment in the community.

The last apothecary: Eric Knott (1896-1993) and 20th-century pharmacy in Scotland.

Eric Knott was the last Apothecary at the Royal Public Dispensary and the last Principal of the Duncan School of Pharmacy. He linked pre-war apothecary practice to post-war chemist dispensing. This paper tracks his career from the Duncan School of Pharmacy, transfer to Heriot-Watt College in 1936, to the close of the Royal Public Dispensary in 1963, when the premises were transferred to the University of Edinburgh. It draws on unpublished archival material and long unseen collections from National Museums Scotland to explore what Knott's career can tell us about the impact of new legislation and the introduction of the NHS on pharmacy in Scotland.

Benito-José Estébanez Mazón (1852-1931): la labor botánica de un farmacéutico rural / Benito-José Estébanez Mazón (1852-1931): the botanical work of a rural pharmacist

Analizamos la actividad botánica y profesional de Benito-José Estébanez Mazón (1852-1931), un farmacéutico rural, establecido en Soncillo (Burgos) y sus relaciones con la Universidad Central a través de Blas Lázaro e Ibiza (1858-1821). Se analiza su participación en dos proyectos fallidos: la constitución de la Federación Regional de los Colegios de Farmacéuticos del Norte de España (1917) y el la propuesta de fundar una estructura estatal dedicada al cultivo y recolección de plantas medicinales (1923)

We analyzed the botanical and professional activities of Benito-José Estébanez Mazón (1852-1931), a rural pharmacist, established in Soncillo (Burgos) and his relations with the Central University through Blas Lázaro (1858-1821). We analyzed his participation in two failed projects: the constitution of a Regional Federation of the Pharmaceutical Colleges of Northern Spain (1917) and the proposal to create a state structure dedicated to the cultivation and collection of medicinal plants (1923)

[Textual research on the engraved prescriptions of Taishan-Stone quoted by ancient medical books].

It is recorded that in Daizong (honorific title of Taishan) in the Song feng shuo yi (Songfeng's Talking of Epidemic Diseases) written by Liu Kui of the Qing Dynasty, some of its prescriptions were derived from the stone wall inscriptions. Some medical historians claim that Liu used the "weird" theory to deify his prescriptions. However, several records of prescriptions engraved in the Taishan stone carving can be retrieved from ancient medical books, proving that what Liu said was true, but not rumors. The Bureau of People's Welfare Pharmacy in the Song Dynasty engraved these prescriptions in the stone at the side of the Yunü Pool on the peak of Taishan. Presently, there are cliff inscriptions at the old site of the Yunü Pool, with its lower part covered in the soil, which might contain these prescriptions.

Joseph Jacobs: Apprentice to Crawford W. Long in Athens, GA; Pharmacist and Retailer of Soda Fountain Beverages in Atlanta, GA.

In the 1870s, Joseph Jacobs was employed as an apprentice in the Longs and Billups pharmacy in Athens, GA. Jacobs later established a chain of pharmacies in Atlanta, GA. Coca-Cola was first sold to the public on May 8, 1886, at Jacobs' Pharmacy in the Five Points district of Atlanta, GA. The soda fountain in Jacobs' Pharmacy was owned by Willis E. Venable, who was related to James M. Venable, the first patient etherized by Crawford Long in Jefferson, GA.

The impact of the Baltic Germans' emigration on the pharmaceutical sector in Latvia (1939-1940).

For several hundred years, the Baltic German families of pharmacists have been the decisive creator of traditions in Latvian pharmacy. A large amount of the oldest pharmacies in Latvia, especially in Riga, were owned by pharmacists of Baltic German origin. Many of these ancient pharmacies ceased to exist in 1939, as a result of the emigration of the Baltic Germans. The agreement on the outward migration of German nationality citizens between Latvia and Germany was signed October 30, 1939. According to the information of the Pharmacy Board of Latvia, the number of employees in the pharmaceutical sector, registered in 1939, was 2068 persons. During the first wave of emigration, at the end of the year 1939, 306 persons, related to pharmacy, renounced the Latvian citizenship and emigrated. During the second wave of emigration, in spring of 1941, when Latvia had already lost its political independence, another 49 pharmaceutic employees left Latvia. In total 355 employees emigrated to Germany. As a result of the Baltic German emigration there was a decreased number of pharmacies in Latvia and the lack of pharmacists became a local issue. In rural areas quite often the only one pharmacy, which had been owned by a German origin pharmacist was liquidated or stayed closed for several months.

From Dispensaries to Community Health Centers: Health Delivery Change Across the Twentieth Century.

This piece examines the historical forces and forebears that preceded, and helped shape, community health centers. Though the current iteration of community health centers date from the 1960s, their (deeper) roots go back to the earliest years of the twentieth century. They began life as largely urban phenomena, and rode the wave of the larger program of Progressive-era political and socioeconomic reforms.

[The Black Eagle pharmacy in Petrinja - first civil pharmacy on the territory of Banska krajina]. / Ljekarna K crnom orlu u Petrinji - prva civilna ljekarna u Banskoj krajini.

The Black Eagle pharmacy was founded in 1772 as a branch of the eponymous Karlovac pharmacy and was the oldest civil pharmacy on the territory of Banska krajina. Based on the archival sources, newspapers of the time, and the documentation preserved within the owner's family, its historical background and ownership chronology are presented in this paper. Special attention was dedicated to the Panac family, which led the pharmacy through four generations, from 1822 until 1950. The results of our research resolved the dilemmas about the pharmacy's first location and also presented the information concerning the academic path of its owners, their work, as well as their wider socio-cultural influences on life in Petrinja. The interior of The Black Eagle pharmacy has not retained its original function nor has the inventory been preserved, although the building, in which it was located, has been preserved and is protected as a cultural monument. The pharmacy was nationalized in 1947, and moved to a new location towards the end of 1950s. Therefore, the reconstruction of its historiography contributes not only to our knowledge of the pharmacy development in Croatia, but also to the understanding of the development of the city through the emergence and existence of medical and healthcare institutions within the city.

[Simplicia and medical containers from the Jesuit pharmacy in Telc]. / Simplicia a nádoby jezuitské lékárny v Telci.

The Jesuit pharmacy in Telc was founded after 1657 within the premises of the Jesuit cloister; it survived the dissolution of Jesuits in 1773 and thanks to its purchase by the last pharmacist Ignac Lyro it was relocated to one of the houses in the square. During the stocktaking of the property and its sale, a detailed inventory of pharmacy equipment was recorded, including cabinets, laboratory tools, ingredients or drugs. The inventory is divided into parts of ingredients and prepared medications, the last lists recording the tools and containers for its preparation, production and preservation. The ingredients contain various parts of plants, minerals, precious stones or even parts of animals. The list is written mainly in the alphabetical order, in some cases with specified types of groups. Every item is provided with information about its price and quantity. Many ingredients originated from overseas countries, the areas of Jesuit missionary activities. Of the former rich equipment, only three pharmacy cabinets and a few containers, mainly veneer boxes and ceramic drug jars, have survived. All these parts together with the inventory give us a comparatively clear notion about the equipment and even facilities of the Jesuit apothecary in Telc, which sold items from different parts of the world. The Jesuit convent seems to be an important centre for town inhabitants not only in the 18th century; its legacy has remained in the local pharmacy till today.Key words: pharmacy Societas Jesus 18th century medications medical containers.